789pprognostic Factors for Survival and Sequencing of Life-extending Therapies in Metastatic Castration Resistant Prostate Cancer (mcrpc) Patients (pts) in Post-docetaxel (d) Setting.

نویسندگان

  • S Oudard
  • A Angelergues
  • I Gonzalez Maeso
  • N Delanoy
  • A Flechon
  • M Özgüroğlu
  • D E Castellano
  • A Guillot
  • S Le Moulec
  • E Esteban
  • J Munarriz
  • B Campos
  • J Bellmunt
چکیده

S. Oudard1, A. Angelergues1, I. Gonzalez Maeso2, N. Delanoy1, A. Flechon3, M. Özgüroğlu4, D.E. Castellano5, A. Guillot6, S. Le Moulec7, E. Esteban8, J. Munarriz9, B. Campos10, J. Bellmunt11 Medical Oncology Service, Georges Pompidou Hospital and Rene Descartes University, Paris, FRANCE Medical Oncology Department, University Hospital del Mar-IMIM, Barcelona, SPAIN Oncology Departement, Centre Léon Bérard, Lyon, FRANCE Department of Medical Oncology, Istanbul University Cerrahpasa, Istanbul, TURKEY Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, SPAIN Medical Oncology, Institut de Cancérologie de la Loire, Saint Priest en Jarez, FRANCE Oncologie Medicale, Hopital du Val de Grace Val de Grace, Paris, FRANCE Oncology Department, Hospital Universitario Central de Asturias, Oviedo, SPAIN Oncology Department, Hospital Provincial de Castellon, Castellon, SPAIN Oncoloxia Médica, Hospital Universitario Lucus Augusti de Lugo, Hospital Universitario Lucus Augusti (Lugo), SPAIN Oncology Department, University Hospital del Mar, Barcelona, SPAIN

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Contemporary agents in the management of metastatic castration-resistant prostate cancer.

Docetaxel-based chemotherapy has been the standard of care for metastatic castration-resistant prostate cancer (mCRPC) since 2004. Over the past few years, there has been a significant paradigm shift in the treatment landscape of this disease. A deeper understanding of prostate cancer biology, along with the development of novel agents has created hope towards treating chemotherapy-naïve and re...

متن کامل

Treatment sequencing in metastatic castrate-resistant prostate cancer

Six different treatments have demonstrated improved survival in phase III trials targeted to patients with metastatic castration-resistant prostate cancer (mCRPC). Front-line therapeutic options for mCRPC include docetaxel, sipuleucel-T, abiraterone and radium-223. Post-docetaxel options include cabazitaxel, abiraterone, enzalutamide and radium-223. Despite much progress in recent years, much i...

متن کامل

Radionuclide Therapies in Prostate Cancer: Integrating Radium-223 in the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer

Metastatic castration-resistant prostate cancer (mCRPC) frequently metastasizes to the bone, often resulting in painful skeletal events, reduced quality of life, and reduced survival. The beta-emitting radiopharmaceuticals strontium-89 and samarium-153 alleviated pain in mCRPC patients with widespread skeletal metastases and have been associated with myelotoxicity. Radium-223, a first-in-class ...

متن کامل

Abiraterone acetate for metastatic castration-resistant prostate cancer post-docetaxel

Abiraterone acetate (AA) 1000-mg daily, a selective irreversible androgen biosynthesis inhibitor of cytochrome P450 c17 (CYP17) enzyme, is used in combination with prednisone 10-mg daily to treat docetaxel-treated patients with metastatic castration-resistant prostate cancer (mCRPC). Several studies have demonstrated the safety and efficacy of this compound in men with mCRPC. Interim results fr...

متن کامل

Chemotherapy in Prostate Cancer Beyond Metastatic CRPC.

During the past decade there has been substantial progress in the treatment of prostate cancer, resulting in the US Food and Drug Administration (FDA) approval of a number of life-prolonging therapeutics for patients with metastatic castration-resistant disease.[1] These accomplishments resulted from our enhanced understanding of the biological mechanisms of androgen receptor (AR) pathway activ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Annals of oncology : official journal of the European Society for Medical Oncology

دوره 25 suppl_4  شماره 

صفحات  -

تاریخ انتشار 2014